Methylcobalamin vs Cyanocobalamin, B12!

Vitamin B-12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. 

B12 is required by humans to use as a cofactor in DNA synthesis in both fatty acid and amino acid metabolism. B12 assists in maintaining a healthy nervous system, circulatory system, red blood cell formation, cell metabolism and immunity. Most people get enough vitamin B-12 from a balanced diet such as eggs and red meat. However, older adults, vegetarians, vegans, and people who have conditions that affect their ability to absorb vitamin B-12 from foods, might benefit from the use of oral supplements or shots. Vitamin B-12 supplements also are recommended for women who are pregnant or breastfeeding exclusively and follow vegetarian or vegan diets.


The average recommended amounts, “Reference Daily Intakes” (RDIs) by US FDA: measured in micrograms (mcg), vary by age:

And recommended “Reference Daily Intakes” (RDIs) by US FDA is:

  • Adults and Children ≥ 4 years: 2.4 mcg
  • Infants through 12 months: 0.5 mcg
  • Children 1 through 3 years: 0.9 mcg
  • Pregnant women and lactating women: 2.8 mcg


Vitamin B12 deficiency can be a serious health problem, according to the European Journal of Clinical Nutrition. Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time.

Vitamin B12 deficiency symptoms may include:

  • strange sensations, numbness, or tingling in the hands, legs, or feet
  • difficulty walking (staggering, balance problems)
  • anemia
  • a swollen, inflamed tongue, Problems with your oral health, like sore tongue and mouth
  • difficulty thinking and reasoning (cognitive difficulties), confusion or memory loss
  • weakness
  • fatigue (Tiredness and weakness)
  • Gastrointestinal problems, like constipation or unexplained weight loss

Some people do not consume enough vitamin B12 to meet their needs, while others cannot absorb enough, no matter how much they take in. As a result, vitamin B12 deficiency is common, especially among older people.


When taken at appropriate doses, vitamin B-12 supplements are considered safe. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, higher doses have been found to be safe. Your body absorbs only as much as it needs, and any excess passes through your urine.

Drug interactions include:

You should always speak with a trusted doctor before adding supplements to your diet, they may recommend a specific dose or might recommend changing drugs or timing doses to offset any potential interactions.


Vitamin B12 (cobalamin) is the largest and most complex vitamin out there. It is unique because it is the only vitamin that contains a metal ion, cobalt (hence its name).

The molecule that is attached to the cobalamin is called a donor. The two most common donors in supplements are cyanide (making the type of B12 known as cyanocobalamin, or cyano B12) and methyl (making methyl-cobalamin, or methyl B12). Two other forms you may find are hydroxocobalamin and adenosyl-cobalamin.

Cyanocobalamin is a manufactured form of vitamin B-12. Bacterial fermentation is used in the industry to produce cyanocobalamin by the addition of potassium cyanide in the presence of sodium nitrite and heat. Once consumed, cyanocobalamin is converted to the biologically active adenosyl or methyl B-12. The two bioactive forms of vitamin B-12. Some individuals lack the enzymatic machinery to convert cyanocobalamin to its metabolic active forms. We at Frunutta have provided our customers with the options of both forms of cyanocobalamin and methylcobalamin B12.


Now, whether you chew, drink, or swallow your vitamin the biggest issue is that the vitamin must survive the stomach acids and then the pancreatic fluids introduced in the small intestine, get absorbed by the intestine and finally survive the liver-bypass metabolism that all food must go through when swallowed.

Minimal of the original vitamin that was swallowed remains to be absorbed. If that was not bad enough vitamin B-12 requires to be bound to a protein called Intrinsic Factor (IF) to be absorbed into our body. As we age our body makes less and less IF and hence, we absorb less B12. Many complain of chronic fatigue or tiredness as they reach their 30’s, 40’s and 50’s which worsens with advancing age.

What is your best option if you do not want to get a B-12 shot in the butt? An excellent source of under the tongue B-12 currently available in the market allows bypass of the harsh environment of the gut or the need for attachment to IF. Under the tongue B-12 is absorbed directly into the bloodstream by osmosis as described above without the need of the Intrinsic Factor (IF). 


The liver is an amazing organ that acts like a laboratory in our body, breaking down all types of toxins and storing them or deactivating them before they can harm us. Our ancestors did not put their livers under the kind of stress that our modern diet does daily. Many are aware that carbohydrates such as simple sugars are not a reliable source of nutrition. Research has shown that most carbohydrates that we consume such as sugar or white rice are lacking any useful vitamins and minerals, hence the liver must store them as fat. However, due to persistent sugar intake in our daily diet the liver continues to be clogged up by fat that it intends to put away in other storage areas and eventually this can be a possible contributing factor for non-alcoholic fatty liver disease. Sugars that are found in fruits and vegetables are mildly better since they come with their own dose of vitamins which can help the liver process the sugars much easier.

New research is showing the importance of vitamins in liver disease, and it may lead the way to simple preventive therapies.

Non-Alcoholic Fatty liver disease is the most common form of liver disease worldwide. For many years’ researchers had seen a link between low levels of vitamin B12 in patients with liver disease. However, a new study is showing a direct link between low levels of Folic Acid (B9) and vitamin B12 and progression of fatty liver disease.  The “study demonstrated that low levels of folate (B9) and vitamin B12 can be used as independent predictors of the histological severity of” liver disease. *

You must always consult your doctor prior to starting on any new vitamins or supplements regimen.


The most critical issue is vitamin absorption which will be touched upon in the next section. However, after bariatric surgery there is a period of hair loss which can be decreased with Biotin supplementation. Most individuals are also B12 deficient since they do not have the portion of the stomach that assists in B12 absorption and in production of Intrinsic Factor. Iron deficiency is also quite common due to fact that aside from nausea and constipation iron supplements require acidic stomach to activate the swallowed pills for absorption. Other commonly found deficiencies are folatevitamin Czinc, and copper. 


Vitamin B12 has many proven benefits and one is in the production of red blood cells. Without the benefit of B12 the body will be unable to produce adequate red blood cells which carry oxygen to the body and that is known as a form of anemia.


Vitamin B12 may help in depression. In a recent study subjects injected with B12 and treated with antidepressants fared better than the group that was only treated with the antidepressant.


Vitamin B12 may assist the body in hair and nail growth and avoid the skin disease Vitiligo, were patches of discolored skin form.


A recent medically reviewed article discussed the benefits of B12 regarding neurological preventative diseases. Vitamin B12 may assist with prevention of dementia in elderly. A study in the American Academy of Neurology monitored 107 patients over 61 years of age for 5 years showing greater rate of atrophy on MRI studies in subjects that were B12 deficient vs. controls. Vitamin B12 appears to be crucial for a well-functioning brain and nervous system. The study concluded that “Low vitamin B12 status should be further investigated as a modifiable cause of brain atrophy and of likely subsequent cognitive impairment in the elderly”.



We at Frunutta provide our customers with two forms of vitamin B-12 so our customers can have a choice in their vitamins, Cyanocobalamin & Methylcobalamin (inactive and active).

Methylcobalamin is slightly more biologically active than cyanocobalamin.

Cyano B12 is a cheaper, synthetic, inactive form of B12 that is made with a cyanide donor and is used commercially. It is the most stable form because the cyanide molecule has the greatest attraction to the cobalamin, so it protects it from conditions like very high temperatures. In fact, the average person in good health will not go wrong with either, remember getting more B12 can never be a bad thing. Methylcobalamin is one of the two active forms of vitamin B12.

Bottom line, in most cases it is a personal preference.

Our under the tongue Micro Quick Absorb technology you will absorb your B-12 vitamin tablet quickly and easily under the tongue without concern for intrinsic factor or shots.

We at Frunutta want to make your hectic life a little easier and healthier!

If you think you may have a vitamin B12 deficiency, talking to your doctor is the best, to determine an excellent course of treatment.

This information is only for educational purposes and is not medical advice or intended as a recommendation of any specific products. Consult your health care provider for more information. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


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