Can you take probiotics Sublingually?

 

Can you take probiotics Sublingually?

The medical community has just begun to understand the advantages that good bacteria bring to our well-being vs. the bad bacteria that are fighting to harm us daily.

The days of solely relying on antibiotics are gone. Hello to the new day of good bacteria helping our gut and skin and our overall health. With this new finding comes the world of probiotics and their differences and their advantages. The subject of Probiotics is too large for us to discuss in this article, and we shall concentrate on why an under the tongue Probiotics is bad for your health.

Under The Tongue Vitamins

We can all agree that vitamins are meant to help our body improve its day-to-day functions. Different vitamins are meant to improve every separate organ system in our body from immunity to mental function, to energy, to blood count and the list goes on and on.

To absorb the vitamins into our system is of the utmost importance and hence Frunutta vitamins are meant to be taken under the tongue to absorb directly into the bloodstream without unnatural additives and preservatives, just pure goodness.

Probiotics for Gut Health

If you are anything like us, then you must know that probiotics are the new craze today. The reason behind them is that your gut is filled with bacteria that are both good and bad for your body. Probiotics help restore the balance between the bad bacteria and the good bacteria. Many of the good bacteria in your gut help your body process food, make vitamins, absorb the food, produce healthy stools.

Overall probiotics help you maintain a healthy load of the good bacteria and allow you to maintain a healthy gut and prevent disease. Many times, antibiotics break down this balance and cause diarrhea and fungal infections to occur due to killing off the good bacteria along with the bad bacteria.

But research is showing that probiotics are more important than just suppression of bad bacteria and improving stool health. The bidirectional communication between the central nervous system and gut microbiota, referred to as the gut-brain-axis, has been of significant interest in recent years. Increasing evidence has associated gut bacteria to both gastrointestinal and extra-gastro-intestinal diseases such as depression, autism, and anxiety. No one can say the exact connection but as research continues new disease associations arise such as dementia, sleep disturbance, joint inflammation that appear to be affected by our gut bacteria and this is compounding our lack of understanding of the overall picture.

In a 30-day study, healthy volunteers with no previous depressive symptoms were given either probiotics or antidepressants. Those given probiotics showed reduced cortisol levels and improved self-reported psychological effects to a similar degree as participants administered Diazepam, a commonly used anti-anxiety medication.

Comparing probiotics to the antidepressant Escitalopram in mice, the probiotics were discovered to have similar effects. They were equally successful in anxiety reduction and were more effective than the Escitalopram in maintaining healthy metabolism and body weight. Though researchers have not determined the mechanism of action in humans, those who studied probiotics in rats found that oral ingestion of Bifidobacterium Longum a very good probiotic per current research resulted in increased levels of Gamma-Aminobutyric Acid (GABA).

As an inhibitory neurotransmitter a recent study in mice may possibly have provided a breakthrough and possibly given a glimpse of GABA’s action at the cellular level. The study in mice shows that brain of fetal mice lacking the ability to produce GABA show burst firings associated with large activity spikes throughout 24 hours.

This study is a strong step in understanding GABA’s suppressive activity in the brain and ultimately the body, hence allowing for rest and peace to set in and overall reduction in anxiety.

When is the Best Time to Take Probiotics?

To get the most out of your probiotic, you are going to want it to stay in the gut, and hence probiotics do not come in injection or under the tongue form- they must stay in the gut.  You never want any bacteria good or bad to be absorbed into the bloodstream since this will cause a condition known as sepsis and is harmful to your body. Hence all probiotics should be swallowed and exposed to the intestinal environment since that is where they do their best.

A probiotic tablet should never be taken at the same time as an antibiotic since this will decrease the effectiveness of both pills. You should at least give 6 hours’ time between taking an antibiotic and your probiotic tablet. Probiotic tablets, drinks or yogurts can be taken on a regular basis. However, some doctors prefer that you do not take them every day and instead take the probiotic on every other day basis. This is to avoid overpopulating your gut with only one type of good bacteria which can also create an imbalance. 

Vitamins and Bacterial Flora

Gut or the intestine is the place where most of the nutrients and water are absorbed into the body through mesenteries. The small intestine and the large intestine are the two major parts of the gut, and the small intestine contains three major parts known as duodenum, jejunum, and ileum. The small intestine absorbs the nutrients of the digested food while the large intestine absorbs water from food. Small intestine is the longest organ of the body, which is usually three times the height of the person.

The microstructure of the gut is extremely adapted for the absorption of food with the presence of villi and microvilli. These microstructures are small projections towards the inner lumen of the intestine, so that the surface area is large and that facilitates more absorption of nutrients from digested food. The networks of capillaries absorb the nutrients through four main processes known as Active transport, Passive diffusion, Endocytosis, and Facilitated diffusion. The duodenum performs two main functions including chemical digestion and absorption, but jejunum and ileum are responsible for absorption. The vitamins, lipids, Irons, sugars, amino acids, and water are absorbed in the gut.

Strains of bacteria found in a healthy human intestine can produce vitamins B1, B2, B5, B6, folate, B12 and K2 and probably also contribute to the supply of these nutrients.

Poor intestinal health (and resultant malabsorption) is one of the main causes of vitamin deficiencies, especially vitamin B12 deficiency, suggesting that many people are a long way from having a healthy enough gut to enable their body to produce its own supply of B12.

Our intestinal flora is today exposed to numerous negative influences such as stress, nutrient deficiencies, antibiotics, drugs, and medications. Therefore, most experts agree that the best way to ingest and absorb B12 is sublingually, or under the tongue since they are highly "bioavailable" (easier to absorb).

Vitamin B12 is one of the most fascinating and complex biological molecules. While all higher forms of life depend on a supply, vitamin B12 can only be produced by certain bacterial species. Neither plants nor animals have acquired the ability to produce the vitamin themselves during evolution, without the help of bacteria. As a result, for a long time, all higher organisms were expected to be dependent on an intake of vitamin B12 from food (or supplement). However, with increasing research into the human microbiome – the collection of bacteria inside and on our body – this understanding has been drawn into question. It is becoming increasingly apparent that complex life forms, such as humans and other animals, may have formed a symbiotic relationship with certain B12-producing bacteria over the course of evolution, which create the vitamin in our intestines and thus contribute to our overall supply. This would be good news and at the same time bad news for vegetarians and vegans who have hardly any B12 sources in their diet.

Although the human body consists of between 10-40 trillion cells, this enormous number is far exceeded by the bacterial population that inhabits our body – by almost a hundredfold. With around one hundred trillion bacterial cells, bacteria are clearly in the majority. Regarding genetic material, bacteria surpass us by far: for every human gene in our body there are around one thousand bacterial genes from up to 10,000 different bacterial strains.

While pathogenic bacteria pose a threat to the body, it is now clear that our body’s ecosystem relies on certain benign bacteria to stay healthy. Evolution has led to a symbiosis between humans and these bacterial strains, which are now an integral part of our metabolic system. Trillions of benign bacteria in our body as well as constantly changing messenger substances, metabolites, genetic material, and nutrients fulfil extremely important biological tasks. These include protection against pathogens, assistance in digesting otherwise indigestible proteins, fats and carbohydrates stimulation of the immune system, and the supply of nutrients. For example, take vitamin B12 and the process of its absorption. Vitamin B12 absorption is an extraordinarily complex process that often becomes less efficient with age, and involves the stomach, pancreas, and small intestine. In healthy adults, about half of the ingested vitamin B12 present in food is absorbed into the body, but loss of function in any of these organs impairs vitamin B12 absorption potentially leading to vitamin B12 deficiency. In the stomach, secreted gastric acid and pepsin are essential to liberate vitamin B12 from the proteins in food that bind it tightly. Once liberated from food, vitamin B12 is bound in the stomach by R-proteins, which carry the vitamin to the intestine. The R-proteins are degraded in the small intestine by proteases secreted from the pancreas which are again enzymes, thereby liberating the vitamin B12. The vitamin B12 does not remain free in the intestine, but rather binds to another carrier protein called Intrinsic Factor (IF), which is secreted by the parietal cells in the stomach. Intrinsic factors cannot bind vitamin B12 in the acidic environment of the stomach, but tightly binds the vitamin in the alkaline pH of the intestine. The vitamin B12-intrinsic factor (IF) complex is transported into the intestinal cells and from the enters circulation

Age plays a significant role in intrinsic factor (IF) production, as it significantly decreases around age 50, therefore intestinal or gut absorption of B12 will be impacted significantly and even probiotics will not deliver their purpose in that age group since their production of B12 will also fail to be absorbed. Hence certain age groups must resort to sublingual (under the tongue) vitamin absorption or intramuscular shot as their way of supplementation.

Summary

Many of our customers have asked us to make an under the tongue probiotic. However, as we explained the probiotics effects must stay in the gut and not be absorbed into the bloodstream. But as discussed above, as we age even the probiotics that we take do not help us absorb the vitamins that we need from our intestines. Hence an under the tongue or sublingual vitamin is essential to supplement us with the vitamins we need without depending on the intestinal absorption.

Frunutta vitamins and supplements are absorbed under the tongue and avoid the absorption issues that plague other ordinary vitamins.

It is good to be extraordinary with Frunutta.

This information is only for educational purposes and is not medical advice or intended as a recommendation of any specific products. Consult your health care provider for more information. These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

References:

  1. World Health Organization. Worldwide Prevalence of Anemia 1993–2005: WHO Global Database on Anemia. World Health Organization, 2008.
  2. Natasha Van Schoor, Paul Lips, et al. Global Overview of Vitamin D Status, Endocrinol Metab Clin North Am. 2017 Dec; 46(4): 845-870. [PubMed abstract]
  3. Sally P Stabler, Robert H Allen, et al. Vitamin B12 deficiency as a worldwide problem, Annu Rev Nutr. 2004; 24:299-326. [PubMed abstract]
  4. National Ambulatory Medical Care Survey: 2016 National Summary Tables; 2016, 1-43.
  5. Cleveland Clinic Mercy Hospital Internet Publication. 42% Percent of Americans Are Vitamin D Deficient. Are You Among Them?. 2018 July.
  6. Lisa Wartenberg, MFA, RD, LD— Medically reviewed by Katherine Marengo LDN, R.D. How Much Iron Do You Need per Day? 2019 Dec. [Healthline]
  7. Hazra et al. Common Variants of FUT2 are Associated with Plasma Vitamin B12 Levels. Nature Genetics Advance Online publication, Sept. 7, 2008, DOI: 10.1038/ng.210
  8. B12 Deficiency in 40% of US Population Proves Concern is Not Just for Vegans
  9. Nicole U Stoffel, MSc, Colin I Cercamondi, PhD, Gary Brittenham, MD, Christophe Zeder, MSc, Anneke J Geurts-Moespot, BSc, Dorine W Swinkels, PhD, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. 2017, Nov. Volume 4, Issue 11, E524-E533 [The Lancet]
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